악악면 경조직 발육에 미치는 Bisphosphonate의 영향
Effects of Bisphosphonates on Developing Hard Tissues of the Jaws in Rats
구강과학- 전남대학교 2001년 13권 2호 p.194 ~ 210
한정우, 김선헌,
소속 상세정보
한정우 ( ) - 전남대학교 치과대학 구강해부학교실
김선헌 ( ) - 전남대학교 치과대학 구강해부학교실
KMID : 0988420010130020194
Abstract
Bisphosphonates are synthetic derivatives of pyrophosphonates and resistant to destruction by phrophosphatase. Bisphosphonates are currently tested for its use in orthodontic movements, osteoporosis and Paget disease treatment and prevention of metastasis in bone cancer. The effects of bisphosphonates on developing hard tissue and their action mechanism have not been elucidated yet.
This study was aimed to invetigate the effects of etidronate and pamidronate, derivatives of bisphosphonate, on hard tissue development and teeth eruption in the jaws using light and electron microscopy and TUNEL stain. The number and size of osteoclasts were also analysed suing Student´s test.
Both etidronate and pamidronate inhibited teeth development and retarded their eruption. The bony trabeculae of the developing jaws in pamidronate treated group were thinner and more immature than those in control group. The size of osteoclasts was not significantly different between control and eitidronate and pamidronate treated groups, whereas the number of osteoclasts for the eruption of the mandibular 1st molar increased in both etidronate and pamidronte treated groups. However, many osteoclasts were detached from bone surface and did not show typical ruffled border in electron microscopic findings in both etidronate and pamidronate treated groups. No TUNEL positive osteoclasts were seen in all groups. Some of the ameloblasts and outer dental epithelial cells were abnomally proliferated and TUNEL positive in both etidronate and pamidronate treated groups.
These findings suggest that bisphosphonates can adversely delay the development of the teeth and hard tissue, so that they should be carefully used in clinics.
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